Description
A sulfonamide antibiotic; bacteriostatic against Streptococcus when at 20 µg/ml; inhibits the growth of 106 clinical isolates of Gonococcus at 0.01% v/v; reduces plasma levels of Streptococcus in infected rabbits; an inhibitor of CAII and CAIX (Kis = 294 and 300 nM, respectively, for the human enzymes); selective for CAII and CAIX over CAI and CAIV (Kis = 3000 and >10,000 nM, respectively, for the bovine and human enzymes); inhibits the growth of S. haemolyticus and E. coli at 300 µM